心肺功能和大脑内液体流动清理废物的能力直接相关。心脏功能变弱，大脑内各种有害蛋白质和其它废物不能通过脑脊液和血液的流通而有效迅速清除，脑残的速度也会加快。衡量心肺功能健康水平的几个比较容易测量或者估算的主要指标：安静时的脉搏，血压，最大摄氧量 (vo2max)
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